Delist entries in the_loop

If you’re using WP_Query to do your loop it should be as simple as getting all the post IDs and then setting them as negative in the p parameter.

For example:

$unwanted_posts = array(); // you must generate this
$unwanted_posts_str="-".implode( ',-', $unwanted_posts );

$args = array(
    'p' => $unwanted_posts_str
);

You can also set this on an existing query using the set() method.