How Add a Save Button to Custom Meta Box without Leave/Stay js Dialog?

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HERE THE SOLUTION:
If you want remove the default publish button and use a custom submit button for your Custom Meta Box, you have to insert the submit_button in a <div class="submitbox" id="submitpost"></div>
e.g. 

<div class="submitbox" id="submitpost">
    <?php submit_button( 'Submit', 'primary', 'publish', false ); ?>
</div>