Yes, it is possible, however your question is not really precise.
What you experience is probably already that it is possible to sort by meta_key even the value of it is a string of some serialized data – it’s just that this is the standard binary sort and WordPress does not take care about that this is a string with serialized data – it’s just a string for the sort.
So the answer is: Yes, but this is not what you ask for.
Next to that answer, there is no feature built into WordPress so far to search for some value inside a meta_value and then sort for that (sub) value.
It is required that you first get the whole result-set and then sort the data your own. This depends a bit on how you want to use it (you have not shared any code, so it is hard to say), technically there are multiple ways to do so.