Not especially, though I would disable it for your entire site if you have the option as a matter of general best practice.
In a well maintained WordPress install, the contents of that directory aren’t a secret, even if the directory listing is hidden.
This is because you should never modify that folder, so it will always match the wp-includes folder in the WordPress download zip.
Anybody could look at WordPress on Github and see the listing, or download the zip, and expect to find the same files in the same locations on your site.
Of course if someone did change their wp-includes folder, then directory listings are the last thing you should be worrying about, as that in of itself is a serious security and maintenance concern.