Essentially, no. If you look at how that plugin stores its mappings:
mysql> desc wp_domain_mapping;
+---------+--------------+------+-----+---------+----------------+
| Field | Type | Null | Key | Default | Extra |
+---------+--------------+------+-----+---------+----------------+
| id | bigint(20) | NO | PRI | NULL | auto_increment |
| blog_id | bigint(20) | NO | MUL | NULL | |
| domain | varchar(255) | NO | | NULL | |
| active | tinyint(4) | YES | | 1 | |
+---------+--------------+------+-----+---------+----------------+
There simply is not a place to put a path.