Wp-query and column blocks

The new block editor gives lots of possibilities to arrange information inside one post. What you are asking for is the arrangement of multiple posts. That’s not a task for the block editor but for the theme.

So, for your question: it depends on the theme whether this is possible. If you are designing your own theme, it is a matter of applying the right css to the post containers. This is a matter of your html/css skills, so it is not WordPress specific and hence outside the scope of this site. You may want to take a look at flexbox, though.