Sure, hook it right onto category_description
.
Here’s an example:
function category_desc_filter( $desc, $cat_id ) {
$desc="Description: " . $desc;
return $desc;
}
add_filter( 'category_description', 'category_desc_filter' );
Didn’t test it but based on the Codex it should work.
See the Codex for more info: http://codex.wordpress.org/Plugin_API/Filter_Reference#Category_and_Term_Filters