You do not need to, instead add the user URL column to the list of searchable table columns
https://developer.wordpress.org/reference/hooks/user_search_columns/
Which includes a user contributed example that does this:
https://developer.wordpress.org/reference/hooks/user_search_columns/#comment-4605
add_filter( 'user_search_columns', 'wpdocs_filter_function_name', 10, 3 );
function wpdocs_filter_function_name( $search_columns, $search, $wp_user_query ) {
$search_columns[] = 'user_url';
return $search_columns;
}
With this, no syncing to a URL field is necessary.