I use WP-SuperCache and since I just use (don’t hack it), then it’s deactivated when I’m on development. I only activate it on production. This might not be quite effective, because you may want to test how caching works on development. However, I found (at least for me) testing in development to be useless since the data and traffic are in the production and not in the development.
So, it might not be an answer, but if you are not doing any hacking for the plugin code, you may want to skip it in development and only activate it in production.