This is very similar to this question.
Try something like this in your template and change the AND condition to AND/OR as appropriate depending on what combination you want.
$args = array(
'post_type' => 'Book',
'tax_query' => array(
'relation' => 'AND',
array(
'taxonomy' => 'Genre',
'field' => 'slug',
'terms' => array( 'Fiction' )
),
array(
'taxonomy' => 'Media Type',
'field' => 'slug',
'terms' => array( 'eBook' )
)
)
);
$query = new WP_Query( $args );