Index page of posts tagged with two separate taxonomies

This is very similar to this question.

Try something like this in your template and change the AND condition to AND/OR as appropriate depending on what combination you want.

$args = array(
'post_type' => 'Book',
'tax_query' => array(
    'relation' => 'AND',
    array(
        'taxonomy' => 'Genre',
        'field' => 'slug',
        'terms' => array( 'Fiction' )
    ),
    array(
        'taxonomy' => 'Media Type',
        'field' => 'slug',
        'terms' => array( 'eBook' )
    )
)
);
$query = new WP_Query( $args );