Profiling with Profiler-Plugins

Not sure exactly what you need to accomplish with your profiling, but WP Tuner (WordPress Plugin) goes a long way to finding what is slowing down your WP install.

It looks at each plugin and give your the memory, CPU time and SQL queries involved.

The SQL Monitor (WordPress Plugin) analyzes SQL performance.

Combine it with W3 Total Cache (WordPress Plugin) and you should get better performance on any platform.

Also, look to using transient API to store fragments you do not need to generate everytime. This can really help on a slow DB.