[^\d\s]
will match a single character that is NOT a digit or whitespace.
[\D\S]
will match a single character that IS a non-digit or non-whitespace.
Since every character is either not a digit or not whitespace, the second regex will match any character.
It’s equivalent to the difference between:
if (!(isdigit(c) || isspace(c))) ...
and
if (!isdigit(c) || !isspace(c)) ...
Note that the following would be equivalent to the first one (by deMorgan’s law):
if (!isdigit(c) && !isspace(c)) ...
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