I unfortnately have no experience with this but evidently it can be done as these articles and plugins address some of the issues:
- HOWTO: Install WordPress On Nginx
- WordPress + nginx Compatibility Plugin
- Howto nginx + wordpress + ubuntu shortest setup
- Nginx front-end proxy cache for WordPress
- WordPress Pretty Permalinks with Nginx
- WordPress, Nginx and WP Super Cache
Also are you familiar with WP Engine WordPress hosting? They are evidently using it in a hybrid form with Apache, probably as a front-end proxy.
Hope these help.
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