Custom Post Type and Labels

you can use:

add_filter('gettext','custom_author_lable');
function custom_author_lable( $input ) {
    global $post_type;
    if( is_admin() && 'your_post_type' == $post_type )
        if ('Author' == $input || 'author' == $input)
                 return 'Keynote Speaker';      
    return $input; 
}

just replace your_post_type.

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