Checkbox on a meta box using CMB2 Plugin

If i get it right, then you just need to get that value from post meta, and make condition.

$image_or_video = get_post_meta($post_id, $prefix . 'image_or_video', true);

// Option 2 is selected
if( 'custom' === $image_or_video ){
 //Then execute some PHP code
}

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