Custom post type as home page with custom url

EDIT
Since, as you mentioned it in comments, it can have several values, maybe we could retrieve the city list and set corresponding rewrite rules like so?

assuming $city_list is an array of cities

foreach ($city_list as $city) {
    add_rewrite_rule('/^'. $city .'/destination/'. $city .'$/','index.php?p=idofyourhomepage','top');
}

How about trying some rewrite rules.

add_rewrite_rule('/^london/destination/london$/','index.php?p=idofyourhomepage','top');

Or

add_rewrite_rule('/^london/destination/london$/','index.php?pagename=nameofyourhomepage','top');

Go validate your permalink settings to refresh the rules.

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