Hook when new CPT published AND postmeta inserted

I believe you can do it using the save_post hook, than do a conditional check for the post’s post-type and the value of its post meta.

add_action( 'save_post', 'do_some_function');
function do_some_function($post_id) {
    global $post;
    $post_type_as_taxonomy = array('cpt-1','cpt-2'); // this is your hooked custom post types
    $post = get_post( $post_id );
    if(in_array($post->post_type, $post_type_as_taxonomy) && $post->post_status=='publish'){ // check if the post is hooked & published
        $my_meta = get_post_meta($post_id, 'my-meta', true); // check if  it has a post meta with the ket 'my-meta'
        if($my_meta){
            // do your hook function here
        }
    }
}