For development I would advise to always work with WP_DEBUG
set to true
and do the following:
$key = 'transient_key';
if( !WP_DEBUG && ( false !== ($transient = get_transient($key)) ){
/* Generate transient manually */
$expiration = 24*60*60;//How long to keep for
set_transient($key,$transient, $expiration);
}
In general – it should be fine deleting transients, as they should never be assumed to be in the database.