Meta box not saving

Since you are using single values anyway, how about trying just:

$meta_SDate = get_post_meta($post->ID,'event_start_date',true);
$meta_EDate = get_post_meta($post->ID,'event_end_date',true);

Also note the following lines will need a space to separate the posted values so strtotime can work properly:

$updStartD = strtotime(trim($_POST['event_start_date']) . ' ' . trim($_POST['event_start_time']));
$updEndD = strtotime(trim($_POST['event_end_date']) . ' ' . trim($_POST['event_end_time']));

I have added trim to remove left and right whitespace just in case too.

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