“NoClassDefFoundError: Could not initialize class” error

When I run my project, I get numerous outputs of this error:

Sep 9, 2009 8:22:23 AM org.apache.catalina.core.StandardWrapperValve invoke
SEVERE: Servlet.service() for servlet Jersey threw exception
java.lang.NoClassDefFoundError: Could not initialize class SpringFactory
        at com.point2.prospect.persistence.hibernate.HibernateTransactionInterceptor.doFilter(HibernateTrans
actionInterceptor.java:17)
        at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
        at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
        at com.point2.prospect.restapi.ServerErrorInterceptor.doFilter(ServerErrorInterceptor.java:27)
        at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
        at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
        at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:233)
        at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:191)
        at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:128)
        at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:102)
        at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:109)
        at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:286)
        at org.apache.coyote.http11.Http11Processor.process(Http11Processor.java:845)
        at org.apache.coyote.http11.Http11Protocol$Http11ConnectionHandler.process(Http11Protocol.java:583)
        at org.apache.tomcat.util.net.JIoEndpoint$Worker.run(JIoEndpoint.java:447)
        at java.lang.Thread.run(Thread.java:619)

I notice that this problem has a pattern of being asked all over the web, but with no real answers. What is a general cause for this kind of error?

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