The exception typically indicates a network routing problem of some kind. This may be the result of a problem with the network configuration in you LAN or WAN, or it may be a result of a network link or switch outage. It can even be cause by failure of the host that you are trying to talk to.
IMO, it is unlikely to be a network firewall issue, though that is also possible. (Normally a firewall will simply discard packets to block traffic, and that is most likely to result in connection timeouts. However, a firewall could respond with an Destination Unreachable packet that would result in this exception.)
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