This can be set in a plugins’ options if you’re using a plugin to generate a Custom Post Type (such as CPT UI).
Otherwise if you’ve created this post type in the functions.php file you should amend or add to your your code as follows:
'with_front' => false
i.e. if your permalink structure appears as:
yourwebsite.co.uk/blog/custom-post-title
then setting this to ‘false’ will make your url something like:
yourwebsite.co.uk/custom-post-title