How to get the 5 most recent comments and each comment 5 most recent replies (children)

To list the most recent (5) comments you can use this code :

$sql = "SELECT DISTINCT ID, post_title, post_password, comment_ID, 
comment_post_ID, comment_author, comment_date_gmt, comment_approved, 
comment_type,comment_author_url, 
SUBSTRING(comment_content,1,50) // NUMBER OF CHARACTERS
AS com_excerpt FROM $wpdb->comments 
LEFT OUTER JOIN $wpdb->posts 
ON ($wpdb->comments.comment_post_ID = $wpdb->posts.ID) 
WHERE comment_approved = '1' 
AND comment_type="" 
AND post_password = '' 
ORDER BY comment_date_gmt 
DESC LIMIT 5"; // NUMBER OF COMMENTS

$comments = $wpdb->get_results($sql);
$output   = $pre_HTML;
$output  .= "\n<ul>";

foreach ($comments as $comment) {
    $output .= "\n<li>"."<a href=\"" . get_permalink($comment->ID) . 
    "#comment-" . $comment->comment_ID . "\" title=\"on " . 
    $comment->post_title . "\">" .strip_tags($comment->comment_author) 
    .":<br/><div>" . strip_tags($comment->com_excerpt) 
    ."</div></a></li>";
}
$output .= "\n</ul>";
$output .= $post_HTML;

echo $output;
?>

It will output the comments in this HTML markup :

<ul>
    <li>
        <a href="http://domain.tld/post#comment-01" title="on Post Title">Comment Author:<br />
        <div>This is the first 50 characters of the first most recent comment</div></a>
    </li>
    <li>
        <a href="http://domain.tld/post#comment-01" title="on Post Title">Comment Author:<br />
        <div>This is the first 50 characters of the first most recent comment</div></a>
    </li>
    <li>
        <a href="http://domain.tld/post#comment-01" title="on Post Title">Comment Author:<br />
        <div>This is the first 50 characters of the first most recent comment</div></a>
    </li>
    <li>
        <a href="http://domain.tld/post#comment-01" title="on Post Title">Comment Author:<br />
        <div>This is the first 50 characters of the first most recent comment</div></a>
    </li>
    <li>
        <a href="http://domain.tld/post#comment-01" title="on Post Title">Comment Author:<br />
        <div>This is the first 50 characters of the first most recent comment</div></a>
    </li>
</ul>

But I am not sure how you can list the comment’s children..
Maybe something like this should give you the first latest comment reply but you will have to tweak it in order to work :

$args = array(
    'status' => 'approve', 
    'number' => '5',
    'post_id' => $post_id,
    'parent' => $parrent

);
$comments = get_comments($args);