Unfortunately not at the moment. If you look in wp-includes/default_constants.php, the WP_CONTENT_DIR and other constants all have a if ( ! defined(constant) ) check before them.
WPINC (the wp-includes constant) does not. It’s defined in wp-settings.php, and has no if ( ! defined(WPINC) ) check, so defining it before hand (in your wp-config.php) would just result in an error.
Also, altering core you could do this, but as soon as you update WordPress, Core files would be reverted, and therefore it would revert back to wp-includes.
I suggestion just masking your site with WordPress in a subdirectory (call it xadw or something nobody would guess) and just set the home URL to be the actual domain. Then put your wp-content folder in another folder, so it won’t be obviously when people look at uploads, etc.
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