Query for user roles and their skills

There is one small issue. You have to user 'IN' instead of = because you want to check values with array

$args = array(

    'role' => 'candidate',
    'meta_query' => array(
    'relation' => 'AND',
    array(
    'key' => 'as_skills',
    'value' => array('skilla','skillx','skille'),
    'compare' => 'IN'
       ),
     ),
 );

$test = get_users($args);   


echo "<pre>";
print_r($test);
echo "</pre>";