Yes, there is a huge difference between while and for.
The for statement iterates through a collection or iterable object or generator function.
The while statement simply loops until a condition is False.
It isn’t preference. It’s a question of what your data structures are.
Often, we represent the values we want to process as a range (an actual list), or xrange (which generates the values) (Edit: In Python 3, range is now a generator and behaves like the old xrange function. xrange has been removed from Python 3). This gives us a data structure tailor-made for the for statement.
Generally, however, we have a ready-made collection: a set, tuple, list, map or even a string is already an iterable collection, so we simply use a for loop.
In a few cases, we might want some functional-programming processing done for us, in which case we can apply that transformation as part of iteration. The sorted and enumerate functions apply a transformation on an iterable that fits naturally with the for statement.
If you don’t have a tidy data structure to iterate through, or you don’t have a generator function that drives your processing, you must use while.