the _edit_lock is generated each time you edit a post or page. it consist the timecode and the user. so WordPress is knowing who is currently editing it.
meta_id post_id meta_key meta_value
9 5 _edit_lock 1388386997:1
if you manipulate it WordPress reacts somehow sensitive …I tried to fetch how many seconds somebody worked on a post. All the time it broke my database loading time.
As you said you running this on a large multisite. Don’t know how many users write posts there, but it definitely could break the RAM of the server if to many people edit a post at the same time.
A solution could be:
get rid of _edit_lock
How to disable the “Post Lock/Edit Lock”?
Normally WordPress should have the “_edit_lock” one per Post. Some databases have the problem generating them every time.
Like this guy
http://wordpress.org/support/topic/can-i-remove-_edit_lock-_edit_last-from-wp_postmeta
His solution was to delete them all.
To speed it up you can delete them all every night at 3 o’clock in phpMyAdmin with
DELETE FROM `yourdb`.`wp_postmeta` WHERE `wp_postmeta`.`meta_key` = '_edit_lock'
might be you find a cron job doing exactly that.