To delete multiple columns at the same time in pandas, you could specify the column names as shown below. The option inplace=True is needed if one wants the change affected column in the same dataframe. Otherwise remove it.
flight_data_copy.drop(['TailNum', 'OriginStateFips',
'DestStateFips', 'Diverted'], axis=1, inplace=True)
Source: Python Pandas – Deleting multiple series from a data frame in one command
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