Selecting/excluding sets of columns in pandas

You can either Drop the columns you do not need OR Select the ones you need

# Using DataFrame.drop
df.drop(df.columns[[1, 2]], axis=1, inplace=True)

# drop by Name
df1 = df1.drop(['B', 'C'], axis=1)

# Select the ones you want
df1 = df[['a','d']]