How to read a .xlsx file using the pandas Library in iPython?

I usually create a dictionary containing a DataFrame for every sheet:

xl_file = pd.ExcelFile(file_name)

dfs = {sheet_name: xl_file.parse(sheet_name) 
          for sheet_name in xl_file.sheet_names}

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Update: In pandas version 0.21.0+ you will get this behavior more cleanly by passing sheet_name=None to read_excel:

dfs = pd.read_excel(file_name, sheet_name=None)

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In 0.20 and prior, this was sheetname rather than sheet_name (this is now deprecated in favor of the above):

dfs = pd.read_excel(file_name, sheetname=None)