Try using the following for your rewrite rules:
location / {
try_files $uri $uri/ /index.php$is_args$args;
}
Using that schema, you can manually remove index.php
from your Permalinks settings without breaking anything. Nginx will now check any URI for its existence as a file on the filesystem, and then a directory on the filesystem, and if neither of those return a valid entry it hands off the entire URI to index.php to process, complete with any query strings if any are present.
For W3 Total Cache, try the following: W3 Total Cache Minify Rewrite Error with WordPress on nginx
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