i think most lightbox plugins require the rel or class attribute to be on the link, so:
<a href="https://wordpress.stackexchange.com/questions/43630/<?php echo wp_get_attachment_url($post->ID); ?>" rel="lightbox" title="<?php echo wp_specialchars( get_the_title($post->ID), 1 ) ?>"><?php echo wp_get_attachment_image($post->ID, 'large' ); ?></a>
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