How to make wordpress theme option page in columns?

If you’re building a custom menu page for your theme options, then you can first use add_menu_page() to register the menu page. Then to use custom styles and scripts on that page, you need to enqueue them on admin_enqueue_scripts action.

Something along these lines,

function my_enqueue_admin_assets() {
  $screen = get_current_screen();
  // only enqueue assets on the custom page
  if ( empty( $screen->id ) || 'your_custom_menu_page_slug' !== $screen->id ) {
    return;
  }
  // wp_enqueue_style( $handle, $src = false, $deps = array(), $ver = false, $media="all" );
  // wp_enqueue_script( $handle, $src = false, $deps = array(), $ver = false, $in_footer = false );
}
add_action( 'admin_enqueue_scripts', 'my_enqueue_admin_assets' );

So enqueue the Bootstrap styles with the above code and then use the appropriate css classes on the markup you write for the add_menu_page() callback.