How to replace NaN values by Zeroes in a column of a Pandas Dataframe?

I believe DataFrame.fillna() will do this for you.

Link to Docs for a dataframe and for a Series.

Example:

In [7]: df
Out[7]: 
          0         1
0       NaN       NaN
1 -0.494375  0.570994
2       NaN       NaN
3  1.876360 -0.229738
4       NaN       NaN

In [8]: df.fillna(0)
Out[8]: 
          0         1
0  0.000000  0.000000
1 -0.494375  0.570994
2  0.000000  0.000000
3  1.876360 -0.229738
4  0.000000  0.000000

To fill the NaNs in only one column, select just that column. in this case I’m using inplace=True to actually change the contents of df.

In [12]: df[1].fillna(0, inplace=True)
Out[12]: 
0    0.000000
1    0.570994
2    0.000000
3   -0.229738
4    0.000000
Name: 1

In [13]: df
Out[13]: 
          0         1
0       NaN  0.000000
1 -0.494375  0.570994
2       NaN  0.000000
3  1.876360 -0.229738
4       NaN  0.000000

EDIT:

To avoid a SettingWithCopyWarning, use the built in column-specific functionality:

df.fillna({1:0}, inplace=True)