Problem saving wordpress settings with current version. Is it a bug?

Sounds like a couple of possibilities

1) an upgrade that may not have completed successfully or fully – try reloading wordpress completely (download and ftp). This has happening to a few folk

or
2)
a plugin that may not be compatible with new version. For debugging purposes, try deactivating one by one till problem goes away (or deactivate all, then reactivate one by one till problem recreated). If no change see 1) above. 🙂