Python read in string from file and split it into values

Something like this – for each line read into string variable a:

>>> a = "123,456"
>>> b = a.split(",")
>>> b
['123', '456']
>>> c = [int(e) for e in b]
>>> c
[123, 456]
>>> x, y = c
>>> x
123
>>> y
456

Now you can do what is necessary with x and y as assigned, which are integers.