Removing a post from the results of a WP Query

Do you know the ID of the posts? Have you passed post__not_in as part of your query?

$query = new WP_Query( array( 'post_type' => 'post', 'post__not_in' => array( 2, 5, 12, 14, 20 ) ) );

From: http://codex.wordpress.org/Class_Reference/WP_Query. The above will return all posts but exclude the IDs specified.

Or do you have another way to group the posts you do not want i.e. by a category or author? A bit of context might help 🙂