There are a variety of ways to create a two-column design in WordPress, where most typically you would use a theme that already has support for doing so.
This page has a pretty nice listing of the different ways that you can create a two-column layout on your site: http://vip.wordpress.com/documentation/how-to-create-columns-in-posts/
You can also go to the wordpress.org Themes Directory and search using their Tags system to narrow down themes that will help you do what you are trying to accomplish. For example:

Related Posts:
- Can you have a blog in a subdirectory hosted on a different server?
- Move WordPress from /blog folder to root but leave post at /blog
- Moving my current wordpress blog to a subdomain
- Could not load the preview image. Please reload the page and try again – error on image upload
- How to display blog posts on a dedicated page?
- Two Blog Layouts, Same Theme
- Show first sentence of blog post in blog roll
- Keep WYSIWYG on Blog Page
- Detect archive and category page
- Custom URL for all posts in WordPress
- List all blog categories
- A garbled copy of MY blog on this site? [closed]
- A different thumbnail to the blog index vs. the image on the top of a post?
- Deleting a blog
- Why does this snippet in a blog post make WordPress crash?
- How to move all theme templates into a subfolder WP
- Where can I find my blog page?
- How to display the posts and news in front page?
- How do I change the taglines next to the featured image on my posts?
- WordPress Blog – Grid View
- How to show latest blog post rather then earliest
- inviting people to blog and editing roles
- Removing blog page images
- problem with wordpress author profile page URL
- How to make blog posts appear under different menu items?
- Portfolio & Blog cohabitation : multiple single.php files?
- How to add list of other blogs, with latest posts from those blogs, to a single page of my website?
- Put post urls into their own category
- I want to display my 2. latest post
- Why the Gutenberg Editor is Not Available In My WP Site?
- How to prevent WordPress from auto creating ol li on list elements?
- How do I add a sign up form to my blog?
- WordPress blog assign unqiue body class
- I am getting “0” in the starting of my post description at home page
- How can I make my Blog category unindexed in Google?
- Recent Posts Listed by Author, Can I exclude authors?
- How to modify display of blog listing page?
- Internal and External Blog
- Can I make a parent page of the blog and have it display a paragraph/thumbnail of certain entries?
- How can I set a vote on the comments?
- Making a column vector in wordpress blog using Latex
- How do you allow users to subscribe to a WordPress blog?
- Blog on a separate server from WooCommerce WITHOUT effecting SEO?
- what is the address of default home page?
- Creating new page overwrites old page
- How to set condition for all posts with one label
- Blogs got Deleted automatically
- Integrate wordpress blog into existing html site
- Retrieve details of my wordpress site
- Blog post stuck in drafts
- I need to customize wordpress “previous” “next” links
- I Have No List Of Blogs – Empty Blog Folder Recreating Itself
- How to change the layout of blog posts to that a compressed snippet shows rather than full text
- Can I create mini-WordPresses on my WordPress?
- How to create library of HTML snippets to use in posts
- Adding a WordPress Blog to a current WordPress site
- Blog Displays Only Sticky Posts
- Uploading a external squeeze page within WP
- Posts page drop down is not selecting the selected page
- URL of blog when using index.php as blog and front-page.php as homepage
- Not showing up on WordPress Reader
- Blog as a part of a WordPress site?
- Fatal error: require() [function.require]: Failed opening required in wordpress
- how to show content of latest blog post with read more link?
- Auto-posting Facebook posts to blog [closed]
- How to access the so called “Posts page”
- Home page of blog displays no posts
- How to turn off “you have to login to comment” on blogs
- How can I get blog content from SFTP?
- Add “Last Edited by” column to custom post type list table
- How I can split text in the_content() into 2 columns?
- Remove “Comment” column in all post-types
- Insert Latest Articles in Homepage
- If newest post of category is newest post in general, skip first post of category
- How to get the post’s parent ID?
- How to post twitter like updates on wordpress
- Manage users custom column add class “num”
- Make a taxonomy column sortable in the admin?
- Blog posts repeat
- wp_enqueue_style and different styles for blog template
- WordPress Plugin manipulate have_posts()
- Functions.php: Exclude Category from “Blog”
- Blog automatically redirected to error page
- How to add columns to wordpress menu editor
- wpdb query with dynamic column name?
- How to set ‘column-primary’ to backoffice 2nd column by default
- Older blog posts not showing up on WordPress
- How can I create a ‘sub-blog’ which has its own sidebar on individual posts?
- How page with random php file with query params generated
- WordPress empty page! what is wrong with this code?
- Error in /blog redirection – ubuntu default WP installation
- Pagination Stops
- How can I change the default image behavior?
- Outputting custom field on home.php not outside of blog list
- Virtual Composer: How to horizontally align contents from two different columns? [closed]
- Columns depending on posts count
- WordPress.com blog migration to self hosted WordPress website [closed]
- Is there a way to create multiple columns of text with alphabetical ordering going down each column not across the columns
- Sorting Users page admin column with ACF field
- column values not showing after merging two custom post types