You can map regular domains to a WordPress Multisite installation using the WordPress MU Domain Mapping plugin.
There’s also a great tutorial available: WordPress 3.0: Multisite Domain Mapping Tutorial
For reference … I asked a similar question yesterday. I have a client who hosts multiple blogs with unique domains, but it becomes a hassle to maintain each one separately. I’m working with them to transition to a Multisite setup instead – single superuser admin, single set of plug-ins, single set of themes, single set of core files … much easier to upgrade and maintain.
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