MetaBox Layout for all users

You could setup a different default layout by hooking into do_meta_boxes, take a look here:

Or you could use the global variable $wp_meta_boxes to do so:

Although the last two links are about dashboard widgets, there is little to none difference in how it is done for meta boxes on edit screens. Doing it with either method would be of course setting this up programmatically. You’d still have to disable the dragging and dropping I guess.