What is the best/safest way to reinstall Homebrew?

Try running the command brew doctor and let us know what sort of output you get


edit: And to answer the title question, this is from their FAQ :

Homebrew doesn’t write files outside its prefix. So generally you can just rm -rf the folder you installed it in.

So following that up with a clean re-install (following their latest recommended steps) should be your best bet.

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