WordPress with php 5.5 and zend opcache

Opcache is transparent for WordPress (as it is to any PHP application).

However if you had been using APC for object cache (key/value store) via plugin — that function is not available in new bundled Zend cache, it only does opcode caching.

You would need to replace object cache with something different (APCu/Memcache/Redis/etc).

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