How can I integrate yepnope.js with WordPress (and plugins)?

I suppose you could use wp dequeue script and then use yepnode, but honestly I don’t see the point with regards to speed since wp_enqueue_script already allows for conditional loading with dependencies.

This is assuming your using well written theme/plugins that allow for the use of the built in function hooks. You can get an array of plugins but you cannot guess how plugin/theme authors are loading scripts.