what is ScriptResource.axd in the page load in web app?

You shouldn’t try to remove requests to those handlers without understanding why the requests are being made. A batch of ScriptResource.axd requests like that are usually due to ASP.NET controls registering includes to the scripts that they’re dependent on, especially scripts for the ASP.NET AJAX Control Toolkit controls.

If you want to minimize the number of individual requests without breaking your site, look into the ScriptManager’s ability to combine multiple scripts into a single payload instead of individual scripts: http://msdn.microsoft.com/en-us/library/cc488552(v=vs.90).aspx

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