You will need to create css
classes for a left and right column (you can use bootstrap if you like) after creating the classes try this
<div class="headlines" data-interval="<?php echo ($interval>0)?$interval*1000:'false'; ?>">
<ul>
<?php
$i = 0;
while ( $r->have_posts() ) {
$r->the_post();
if($i % 2 == 0){ //even line
?>
<li class="left-col"><a href="https://wordpress.stackexchange.com/questions/191730/<?php the_permalink(); ?>"><?php the_title(); ?></a><span class="time_diff"><?php echo ' - ' . dw_human_time_diff( get_the_time('U'), current_time('timestamp') ); ?></span></li>
<?php } else { ?>
<li class="right-col"><a href="https://wordpress.stackexchange.com/questions/191730/<?php the_permalink(); ?>"><?php the_title(); ?></a><span class="time_diff"><?php echo ' - ' . dw_human_time_diff( get_the_time('U'), current_time('timestamp') ); ?></span></li>
<?php };
$i++; }
?>
</ul>
</div>