How to test if blog page is active

There’s a site option for page_for_posts, so you might try if ( is_page( get_option('page_for_posts') ) ).

Edit: According to the Codex, is_home() will tell you if you’re on the blog page when you have a static front page: http://codex.wordpress.org/Conditional_Tags#The_Main_Page. I can’t test it right at this moment, but if that’s true, then that must be what you’re looking for. I guess I hadn’t had to do this before, really good to know.