Pagination is not working wp_query custom fields values

you need to add global $paged and then in your array that is being passed to WP_Query you need to add ‘paged’ => $paged

global $paged;
$temp = $wp_query;
                    $wp_query = null;

                    $wp_query = new WP_Query( array( 'meta_key' => 'wpcf-gender', 'meta_value' => '1', 'meta_compare' => '==', 'post_type' => 'profile','posts_per_page' => 2, 'paged' => $paged ) );

and so forth