Here’s how I take your question, and an answer that is very close to @David Arenburg’s in the comment above.
data <- '"I am a, new comer","to r,"please help","me:out","here"'
gsub('[[:punct:] ]+',' ',data)
[1] " I am a new comer to r please help me out here "
The extra space after [:punct:] is to add spaces to the string and the + matches one or more sequential items in the regular expression. This has the side effect, desirable in some cases, of shortening any sequence of spaces to a single space.
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