Simplest way to profile a PHP script

The PECL APD extension is used as follows:

<?php
apd_set_pprof_trace();

//rest of the script
?>

After, parse the generated file using pprofp.

Example output:

Trace for /home/dan/testapd.php
Total Elapsed Time = 0.00
Total System Time  = 0.00
Total User Time    = 0.00


Real         User        System             secs/    cumm
%Time (excl/cumm)  (excl/cumm)  (excl/cumm) Calls    call    s/call  Memory Usage Name
--------------------------------------------------------------------------------------
100.0 0.00 0.00  0.00 0.00  0.00 0.00     1  0.0000   0.0009            0 main
56.9 0.00 0.00  0.00 0.00  0.00 0.00     1  0.0005   0.0005            0 apd_set_pprof_trace
28.0 0.00 0.00  0.00 0.00  0.00 0.00    10  0.0000   0.0000            0 preg_replace
14.3 0.00 0.00  0.00 0.00  0.00 0.00    10  0.0000   0.0000            0 str_replace

Warning: the latest release of APD is dated 2004, the extension is no longer maintained and has various compability issues (see comments).