The connection to the website was reset. Error Code: INET_E_DOWNLOAD_FAILURE

I am getting the following error from my website:

The connection to the website was reset. Error Code: INET_E_DOWNLOAD_FAILURE

The website is available on Firefox and Chrome, but will not display on IE/Edge. We host this site on our webserver. All other websites are ok. This is an older Aspx Web application using CLR v2.

I have tried a couple of fixes suggested by Microsoft:

The Error Code: INET_E_DOWNLOAD_FAILURE means that the connection was interrupted or it failed to download the content. Let’s start by restoring the advanced settings in the Internet Options.

Go to Internet Options (type it in the Cortana search box) > Advanced tab > click Restore advanced settings > uncheck “Do not save encrypted pages to disk.” After that, click Apply and OK. Let us know how it went by posting back.

Which had no effect also I cleared the browser cache, flushed the DNS via IpConfig and even set up a new website in IIS with a new App Pool, all to no effect.

The error message is very generic so I am a bit lost, especially as the site is visible to FF and Chrome.

Any help greatly appreciated

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